Jaffé reaction interference.
نویسندگان
چکیده
منابع مشابه
Positive interference with the Jaffé reaction by cephalosporin antibiotics.
Cephaloglycin, cephalothin, cephaloridine, cefoxitin, and cephacetrile are cephalosporin antibiotics that react with alkaline picrate solution to give a creatinine-like response. The mechanism of this reaction is not known, and several structurally similar compounds do not react under these same conditions. Because large quantities of a cephalosporin antibiotic may be administered to a patient ...
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errors ofmetabolism currently depends on sophisticated biochemical analysis. NMR analysis can simultaneously analyze the mixture of compounds in biological fluids, but complete analysis of biological fluids by NMR will not be necessitated. Accurate diagnosis should await the results by authenticated methods. Quickness is important. As might be seen from our paper, the need to pretreat urine to ...
متن کاملA simplified procedure for eliminating the negative interference of bilirubin in the Jaffé reaction for creatinine.
The negative interference by bilirubin in the measurement of creatinine by the Jaffé procedure is well documented. We describe a procedure for the elimination of interfering bilirubin by oxidation to biliverdin through the addition of potassium ferricyanide before the alkaline picrate reagent. We detected no negative interference with the addition of as much as 600 mumol/L bilirubin. The proced...
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Bilirubin causes underestimation of serum creatinine in the Jaffé alkaline picrate assay. We report an approach for preventing bilirubin interference by pretreating serum samples with peroxidase and H2O2. The dissociation of bilirubin from albumin and its subsequent oxidation markedly reduces the bilirubin interference and enables accurate determination of creatinine concentrations by the Jaffé...
متن کاملNitromethane interferes in assay of creatinine by the Jaffé reaction.
A patient who ingested a methanol/nitromethane mixture (model airplane fuel) showed an apparent plasma creatinine concentration of 8.0 mmol/L by the Jaffé reaction when the actual creatinine concentration, as measured by a specific enzymatic method, was 0.09 mmol/L. This effect was due to nitromethane in the plasma. Interference by nitromethane with the determination of creatinine by reaction w...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1988
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/34.3.642